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Lymphocytic choriomeningitis : ウィキペディア英語版 | Lymphocytic choriomeningitis
Lymphocytic choriomeningitis (LCM), is a rodent-borne viral infectious disease that presents as aseptic meningitis, encephalitis or meningoencephalitis. Its causative agent is the Lymphocytic Choriomeningitis Virus (LCMV), a member of the family Arenaviridae. The name was coined by Charles Armstrong in 1934.〔Edward A. Beeman: ''Charles Armstrong, M.D.: A Biography'', 2007 pp. 183ff. (also online (here (PDF) )〕 == Definition == The Gale Encyclopedia of Medicine defines lymphocytic choriomeningitis (LCM) as “a viral infection of the membranes surrounding the brain and spinal cord and of the cerebrospinal fluid.”〔Lasker, Jill S. "Lymphocytic choriomeningitis."〕 The name is based on the tendency of an individual to have abnormally high levels of lymphocytes during infection. Choriomeningitis is “cerebral meningitis in which there is marked cellular infiltration of the meninges, often with a lymphocytic infiltration of the choroid plexuses.”〔"choriomeningitis"〕 There are several strains of LCM virus, among which the most widely used are LCMV Armstrong and LCMV Clone 13. Armstrong is the original virus strain which was isolated from the brain by Charles Armstrong in 1934. It triggers a vigorous cytotoxic T lymphocytes(CTL) response and thus, it is cleared rapidly by the host. This is referred to as acute (Armstrong) LCMV infection. On the other hand, Clone 13 is a variant of the Armstrong viral strain, isolated from the spleen and is consequently tropic for visceral organs. It was first isolated from mice which sustained a persistent LCMV infection from birth.〔 This variant potentiates a less vigorous CTL response in the immune system, and thus can ultimately persist in the host organism indefinitely. The latter is referred to as chronic (Clone 13) LCMV infection.〔
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